Syncing with iTunes is required to use MSB
MSB should work on any system (Mac or PC) that meets the current requirements for syncing an iOS device.
Windows Internet Explorer 8 or better. Windows versions below 10 require installation of Microsoft’s Universal C Runtime
macOS 10.14 [Mojave] requires authorization to access backup directories. Use System Preferences > Security & Privacy to give MSB access. See Notes on Mojave for more information.
Emoji display 🆗 requires your system have an Emoji-capable font installed.